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Dr. Vivek TANAVDE
Principal Investigator
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| Group Members |
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| Name | Title |
| Dr. TANAVDE Vivek |
Principal Investigator |
| Ms. LIM Jiahao, Daisy |
Research Associate |
| Ms. NG Soo Lee, Felicia |
Research Associate |
| Ms. TAN Bee Tee Betty |
Research Associate |
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Research Overview
Adult stem cells have the potential to differentiate into a wide variety of tissue specific cells. These cells can therefore be used to treat a variety of disorders ranging from myocardial infarction to osteoporosis. Although hematopoietic stem cells found in the marrow have been well studied for many decades and are routinely used for treating hematological disorders, there is increased interest in mesenchymal stem cells which are the non hematopoietic stem cells found in the marrow. Although these cells are already being used clinically, very little is known about the mechanisms these cells use to differentiate to different lineages. Using gene expression analysis, this group aims to understand these mechanisms and use this information for designing better media suitable for the targeted differentiation of mesenchymal stem cells.
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| More Details |
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| Selected Publications |
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- Ng F, Boucher S, Koh S, Sastry KS, Chase L, Lakshmipathy U, Choong C, Yang Z, Vemuri MC, Rao MS, Tanavde V.
PDGF, TGF-b and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSC into adipogenic, chondrogenic and ostoegenic lineages.
Blood. 2008 Mar 10; [Epub ahead of print]
PMID: 18332228 [PubMed - as supplied by publisher]
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