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Dr. Vladimir KUZNETSOV
Principal Investigator
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| Areas of Research Interest |
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- Study of gene expression pattern and analysis of macromolecular structures and interactions
- Complexities of gene and genome architecture, transcriptome regulation and their relevance for phenotypic properties of cells
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| Biography |
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Dr Vladimir Kuznetsov was appointed Principal Scientist and Head of the Genome and Gene Expression Data Analysis Division at the Bioinformatics Institute (BII), A*STAR in November 2007.
Dr Kuznetsov obtained his degree in Physics at Kyrghyz State University (Kyrghyz Republic, Soviet Union). He went on to obtain a PhD in Biophysics at Moscow State University (Russian Federation, Soviet Union). While he was a postgraduate student at the Institute of Molecular Biology (Moscow), Dr Kuznetsov simultanenously worked as a Junior Scientist at the Research Institute of Oncology and Radiology (Kyrghyz Republic) and a lecturer at the Department of Mathematics and Mechanics. In 1992, Dr Kuznetsov received a Doctor of Science degree in Mathematics and Physics at the Technical Union of Russian Academy of Sciences (St. Petersburg, Russian Federation).
In 1992, Dr Kuznetsov was appointed to head a laboratory in the Institute of Chemical Physics (Moscow). In 1995, he was awarded a prestige one year scholar grant by the American Cancer Society/International Union against Cancer. He worked as a researcher scholar at the Laboratory of Molecular Tumor Biology, Centre for Biological Evaluation, FDA (Bethesda, MD, USA), where he made his experimental study and computational modeling of the dynamics of IL-13 receptor subunits expressed in human solid tumor cells. He later worked as an exchange research fellow and a senior research fellow at the National Cancer Institute and the National Institute of Child Health and Human Development of the National Institutes of Health (MD, USA), where he was involved in the NIH Cancer Genome Anatomy Project. He also served as Chief Scientist at the Civilised Software Inc. (Bethesda, MD) and as a Senior Member of the professional staff at System Research Applications International Inc. (Farfax, VA, USA).
In 2004, he joined the Genome Institute of Singapore as a Senior Group Leader. Currently, Dr Kuznetsov holds adjunct appointments in the Mathematical Department of the National University of Singapore, and in the School of Computing Engineering of Nanyang Technological University, Singapore.
Dr Kuznetsov has made significant contributions to the field of science. In 1994, he was awarded the P.L Kapitsa Silver Medal "To the Author of Scientific Discovery" and elected as a Corresponding Member the Russian Academy of Natural Sciences. Dr Vladimir Kuznetsov has published over 80 research papers and reviews, and is a member of the editorial boards of international journals including Biology Direct and Journal of Integrative Bioinformatics. He is known internationally for his works on basic models of mathematical immunology of cancer, probabilistic models of gene expression analyzed based on SAGE and microarray data, statistical simulation of protein-DNa interaction avidity based on ChIP-PET data, modeling of evolution of proteome complexity, stochastic process models leading to Pareto-like scale-dependent evolution dynamics. Dr Kuznetsov is an inventor of the pattern recognition algorithm – Statistically Weighed Voting method.
This algorithm allows for the selection of a small number of variables from high dimension (e.g. microarray) data and provides robust individual prediction even if the original data set is noisy, contains missing values and is represented by very limited number of samples.
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| Selected Publications |
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- Kuznetsov VA, Orlov YL, Wei CL, Ruan YJ.
Computational Analysis and Modeling of Genome-scale Avidity Distribution of Transcription Factor Binding Sites in Chip-PET Experiments. (Eds. Miyano S, DeLisi C, Holzhütter HG, Kanehisa M).
Imperial College Press London-Singapore. 2007. Vol.19: 83-94
- Zhao XD, Han X, Chew JL, Liu J, Chiu KP, Choo A. Orlov YL, Sung WK, Shahab A. Kuznetsov VA, Bourque G, Oh S, Ruan Y, Ng HH.
Whole Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic compartments in Human Embryonic Stem Cells.
Cell Stem Cell. 2007 Sep;1(3): 286-298
- Ivshina AV, George J, Senko O, Mow B, Putti TC, Smeds J, Lindahl T, Pawitan Y, Hall P, Nordgren H, Wong JE, Liu ET, Bergh J, Kuznetsov VA, Miller LD.
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.
Cancer Res. 2006 Nov 1;66(21):10292-301.
PMID: 17079448 [PubMed - indexed for MEDLINE]
- Liu ET, Kuznetsov VA, Miller LD.
In the pursuit of complexity: systems medicine in cancer biology.
Cancer Cell. 2006 Apr;9(4):245-7. Review.
PMID: 16616330 [PubMed - indexed for MEDLINE
- Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y.
A global map of p53 transcription-factor binding sites in the human genome.
Cell. 2006 Jan 13;124(1):207-19.
PMID: 16413492 [PubMed - indexed for MEDLINE]
- Kuznetsov, VA.
Scale-dependent Statistics of the number of Transcripts and Protein Sequence Encoded in the Genome. In: Computational and Statistical Methods to Genomics. (Eds. Zhang W, Shmulevich I).
Springer, USA. 2nd edition. 2006: 160-208.
- Broët P, Kuznetsov VA, Bergh J, Liu ET, Miller LD.
Identifying gene expression changes in breast cancer that distinguish early and late relapse among uncured patients.
Bioinformatics. 2006 Jun 15;22(12):1477-85. Epub 2006 Mar 21.
PMID: 16551658 [PubMed - indexed for MEDLINE]
- Zucchi I, Mento E, Kuznetsov VA, Scotti M, Valsecchi V, Simionati B, Vicinanza E, Valle G, Pilotti S, Reinbold R, Vezzoni P, Albertini A, Dulbecco R.
Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis.
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18147-52. Epub 2004 Dec 17.
PMID: 15608061 [PubMed - indexed for MEDLINE]
- Kuznetsov VA, Knott GD, Bonner RF.
General statistics of stochastic process of gene expression in eukaryotic cells.
Genetics. 2002 Jul;161(3):1321-32.
PMID: 12136033 [PubMed - indexed for MEDLINE]
- Belyakov IM, Hel Z, Kelsall B, Kuznetsov VA, Ahlers JD, Nacsa J, Watkins DI, Allen TM, Sette A, Altman J, Woodward R, Markham PD, Clements JD, Franchini G, Strober W, Berzofsky JA.
Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques.
Nat Med. 2001 Dec;7(12):1320-6.
PMID: 11726972 [PubMed - indexed for MEDLINE]
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Please contact us by email if you wish a reprint from any of the selected publications. |
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