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  Biography Details
 
Dr. Sebastian MAURER-STROH
Principal Investigator
 
Areas of Research Interest
 
Sebastian Maurer-Stroh's research interests lies in mapping the uncharted islands in functional protein sequence space. This includes inferring functions for uncharacterized genes/proteins based on remote evolutionary relationships, prediction of the 3-dimensional structure of proteins, identification of biologically important residues and disease-related mutations, as well as developing predictors for short functional motifs in protein sequences.
 
Biography
 
Sebastian Maurer-Stroh studied theoretical biochemistry in the group of Peter Schuster at the University of Vienna and wrote his master and PhD thesis while working in Frank Eisenhaber's Group at the Institute of Molecular Pathology (IMP) in Vienna. After a Marie Curie Postdoc fellowship at the VIB-SWITCH lab in Brussels, he joined the Biomolecular Function Discovery Group at Bioinformatics Institute A*STAR Singapore. He has contributed widely used predictors for posttranslational lipid modifications and catalyzed new biomolecular insights by sequence-based function predictions.
 
Selected Publications
 
  1. Sirota FL, Héry-Huynh S, Maurer-Stroh S, Wodak SJ.
    Role of the amino acid sequence in domain swapping of the B1 domain of protein G.
    Proteins. 2008 Jan 10; [Epub ahead of print]
    PMID: 18186476 [PubMed - as supplied by publisher]


  2. Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C.
    Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
    Neurology. 2008 Jan 9; [Epub ahead of print]
    PMID: 18184915 [PubMed - as supplied by publisher]


  3. Reumers J, Conde L, Medina I, Maurer-Stroh S, Van Durme J, Dopazo J, Rousseau F, Schymkowitz J.
    Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases.
    Nucleic Acids Res. 2008 Jan;36(Database issue):D825-9. Epub 2007 Dec 17.
    PMID: 18086700 [PubMed - in process]


  4. Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
    Towards complete sets of farnesylated and geranylgeranylated proteins.
    PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.
    PMID: 17411337 [PubMed - indexed for MEDLINE]


  5. van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, De Deyn PP, Rousseau F, Brice A, Van Broeckhoven C.
    Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
    Hum Mutat. 2007 Apr;28(4):416.
    PMID: 17345602 [PubMed - indexed for MEDLINE]


  6. Reumers J, Maurer-Stroh S, Schymkowitz J, Rousseau F.
    SNPeffect v2.0: a new step in investigating the molecular phenotypic effects of human non-synonymous SNPs.
    Bioinformatics. 2006 Sep 1;22(17):2183-5. Epub 2006 Jun 29.
    PMID: 16809394 [PubMed - indexed for MEDLINE]


  7. Benetka W, Koranda M, Maurer-Stroh S, Pittner F, Eisenhaber F.
    Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.
    BMC Biochem. 2006 Feb 28;7:6.
    PMID: 16507103 [PubMed - indexed for MEDLINE]


  8. Maurer-Stroh S, Eisenhaber F.
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.
    PMID: 15960807 [PubMed - indexed for MEDLINE]


  9. Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
    The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
    Mol Cell. 2005 May 27;18(5):543-53.
    PMID: 15916961 [PubMed - indexed for MEDLINE]


  10. Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T.
    Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
    Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9. Epub 2004 Jul 19.
    PMID: 15263099 [PubMed - indexed for MEDLINE]


  11. Eisenhaber B, Eisenhaber F, Maurer-Stroh S, Neuberger G.
    Prediction of sequence signals for lipid post-translational modifications: insights from case studies.
    Proteomics. 2004 Jun;4(6):1614-25.
    PMID: 15174131 [PubMed - indexed for MEDLINE]


  12. Maurer-Stroh S, Eisenhaber F.
    Myristoylation of viral and bacterial proteins.
    Trends Microbiol. 2004 Apr;12(4):178-85. Review. No abstract available.
    PMID: 15051068 [PubMed - indexed for MEDLINE]


  13. Maurer-Stroh S, Gouda M, Novatchkova M, Schleiffer A, Schneider G, Sirota FL, Wildpaner M, Hayashi N, Eisenhaber F.
    MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.
    Genome Biol. 2004;5(3):R21. Epub 2004 Feb 13.
    PMID: 15003124 [PubMed - indexed for MEDLINE]


  14. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.
    TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
    Curr Biol. 2003 Sep 2;13(17):1459-68.
    PMID: 12956947 [PubMed - indexed for MEDLINE]


  15. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases: anchor size, pseudogenes and parasites.
    Biol Chem. 2003 Jul;384(7):977-89. Review.
    PMID: 12956414 [PubMed - indexed for MEDLINE]


  16. Eisenhaber F, Eisenhaber B, Kubina W, Maurer-Stroh S, Neuberger G, Schneider G, Wildpaner M.
    Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1.
    Nucleic Acids Res. 2003 Jul 1;31(13):3631-4.
    PMID: 12824382 [PubMed - indexed for MEDLINE]


  17. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence.
    J Mol Biol. 2003 May 2;328(3):581-92.
    PMID: 12706718 [PubMed - indexed for MEDLINE]


  18. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences.
    J Mol Biol. 2003 May 2;328(3):567-79.
    PMID: 12706717 [PubMed - indexed for MEDLINE]


  19. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases.
    Genome Biol. 2003;4(4):212. Epub 2003 Apr 1. Review.
    PMID: 12702202 [PubMed - indexed for MEDLINE]


  20. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F.
    Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
    Mol Cell. 2003 Mar;11(3):571-5.
    PMID: 12667442 [PubMed - indexed for MEDLINE]


  21. Eisenhaber B, Maurer-Stroh S, Novatchkova M, Schneider G, Eisenhaber F.
    Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.
    Bioessays. 2003 Apr;25(4):367-85. Review.
    PMID: 12655644 [PubMed - indexed for MEDLINE]


  22. Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
    The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
    Trends Biochem Sci. 2003 Feb;28(2):69-74.
    PMID: 12575993 [PubMed - indexed for MEDLINE]


  23. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence.
    J Mol Biol. 2002 Apr 5;317(4):541-57.
    PMID: 11955008 [PubMed - indexed for MEDLINE]


  24. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences.
    J Mol Biol. 2002 Apr 5;317(4):523-40.
    PMID: 11955007 [PubMed - indexed for MEDLINE]


  25. Flamm C, Hofacker IL, Maurer-Stroh S, Stadler PF, Zehl M.
    Design of multistable RNA molecules.
    RNA. 2001 Feb;7(2):254-65.
    PMID: 11233982 [PubMed - indexed for MEDLINE]


 

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