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  Biography Details
 
Dr. Frank EISENHABER
Head of Division
 
Areas of Research Interest
 
Frank Eisenhaber's research interest is focused on the discovery of new biomolecular mechanisms with theoretical and biochemical approaches and the functional characterization of yet uncharacterized genes and pathways. Frank Eisenhaber is one of the scientists credited with the discovery of the SET domain methyltransferases, ATGL, kleisins, many new protein domain functions and with the development of accurate prediction tools for posttranslational modifications and subcellular localizations.
 
Biography
 
Frank Eisenhaber studied mathematics at the Humboldt-University in Berlin and biophysics and medicine at the Pirogov Medical University in Moscow. He was awarded a MD in 1985. Three years later, he received the PhD in molecular biology from the Engelhardt Institute of Molecular Biology in Moscow (supervision by Dr. Vladimir Gayevich Tumanyan). After postdoctoral work at the Institute of Molecular Biology in Berlin-Buch (1989-1991) and at the EMBL in Heidelberg (1991-1999), he worked as teamleader of the bioinformatics research group and head of the general IT department at the Institute of Molecular Pathology (IMP) in Vienna (1999-2007). Since August 2007, he is the Director of the Bioinformatics Institute A*STAR Singapore.
 
Selected Publications
 
  1. Burkard,T.R., Trajanoski,Z., Novatchkova,M., Hackl,H., and Eisenhaber,F. 2007. Identification of new targets using expression profiling. In Antiangiogenic cancer therapy. D.R.Davis, Herbst,R.S., and Abbruzzese,J.L., editors. CRC Press Taylor & Francis Group. Boca Raton London New York. 2007: 415-441.


  2. Eisenhaber B, Eisenhaber F.
    Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?
    Curr Protein Pept Sci. 2007 Apr;8(2):197-203. Review.
    PMID: 17430201 [PubMed - indexed for MEDLINE]


  3. Eisenhaber B, Chumak N, Eisenhaber F, Hauser MT.
    The ring between ring fingers (RBR) protein family.
    Genome Biol. 2007;8(3):209. Review.
    PMID: 17367545 [PubMed - indexed for MEDLINE]


  4. Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
    Towards complete sets of farnesylated and geranylgeranylated proteins.
    PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.
    PMID: 17411337 [PubMed - indexed for MEDLINE]


  5. Neuberger G, Schneider G, Eisenhaber F.
    pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.
    Biol Direct. 2007 Jan 12;2:1.
    PMID: 17222345 [PubMed]


  6. Benetka W, Koranda M, Maurer-Stroh S, Pittner F, Eisenhaber F.
    Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.
    BMC Biochem. 2006 Feb 28;7:6.
    PMID: 16507103 [PubMed - indexed for MEDLINE]


  7. Eisenhaber F. Prediction of Protein Function: Two Basic Concepts and One Practical Recipe. Chapter 3 in "Discovering Biomolecular Mechanisms with Computational Biology" (Ed. Eisenhaber F). Georgetown: Landes Biosciences and Eurekah.com. 1st edition. 2006: 39-54.


  8. Eisenhaber F. Bioinformatics: Mystery, Astrology or Service Technology. Preface for "Discovering Biomolecular Mechanisms with Computational Biology" (Ed. Eisenhaber F). Georgetown: Landes Biosciences and Eurekah.com. 1st edition. 2006: 1-10.


  9. Mujezinovic N, Raidl G, Hutchins JR, Peters JM, Mechtler K, Eisenhaber F.
    Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise.
    Proteomics. 2006 Oct;6(19):5117-31.
    PMID: 16955515 [PubMed - indexed for MEDLINE]


  10. Schneider G, Neuberger G, Wildpaner M, Tian S, Berezovsky I, Eisenhaber F.
    Application of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases.
    BMC Bioinformatics. 2006 Mar 21;7:164.
    PMID: 16551354 [PubMed - indexed for MEDLINE]


  11. Betschinger J, Eisenhaber F, Knoblich JA.
    Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.
    Curr Biol. 2005 Feb 8;15(3):276-82.
    PMID: 15694314 [PubMed - indexed for MEDLINE]


  12. Hackl H, Burkard TR, Sturn A, Rubio R, Schleiffer A, Tian S, Quackenbush J, Eisenhaber F, Trajanoski Z.
    Molecular processes during fat cell development revealed by gene expression profiling and functional annotation.
    Genome Biol. 2005;6(13):R108. Epub 2005 Dec 19.
    PMID: 16420668 [PubMed - indexed for MEDLINE]


  13. Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
    The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
    Mol Cell. 2005 May 27;18(5):543-53.
    PMID: 15916961 [PubMed - indexed for MEDLINE]


  14. Maurer-Stroh S, Eisenhaber F.
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.
    PMID: 15960807 [PubMed - indexed for MEDLINE]


  15. Novatchkova M, Bachmair A, Eisenhaber B, Eisenhaber F.
    Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.
    BMC Bioinformatics. 2005 Feb 7;6:22.
    PMID: 15698469 [PubMed - indexed for MEDLINE]


  16. Eisenhaber B, Eisenhaber F, Maurer-Stroh S, Neuberger G.
    Prediction of sequence signals for lipid post-translational modifications: insights from case studies.
    Proteomics. 2004 Jun;4(6):1614-25.
    PMID: 15174131 [PubMed - indexed for MEDLINE]


  17. Maurer-Stroh S, Eisenhaber F.
    Myristoylation of viral and bacterial proteins.
    Trends Microbiol. 2004 Apr;12(4):178-85. Review. No abstract available.
    PMID: 15051068 [PubMed - indexed for MEDLINE]


  18. Neuberger G, Kunze M, Eisenhaber F, Berger J, Hartig A, Brocard C.
    Hidden localization motifs: naturally occurring peroxisomal targeting signals in non-peroxisomal proteins.
    Genome Biol. 2004;5(12):R97. Epub 2004 Nov 30.
    PMID: 15575971 [PubMed - indexed for MEDLINE]


  19. Novatchkova M, Eisenhaber F.
    Linking transcriptional mediators via the GACKIX domain super family.
    Curr Biol. 2004 Jan 20;14(2):R54-5. No abstract available.
    PMID: 14738747 [PubMed - indexed for MEDLINE]


  20. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R.
    Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
    Science. 2004 Nov 19;306(5700):1383-6.
    PMID: 15550674 [PubMed - indexed for MEDLINE]


  21. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence.
    J Mol Biol. 2003 May 2;328(3):581-92.
    PMID: 12706718 [PubMed - indexed for MEDLINE]


  22. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences.
    J Mol Biol. 2003 May 2;328(3):567-79.
    PMID: 12706717 [PubMed - indexed for MEDLINE]


  23. Novatchkova M, Leibbrandt A, Werzowa J, Neubüser A, Eisenhaber F.
    The STIR-domain superfamily in signal transduction, development and immunity.
    Trends Biochem Sci. 2003 May;28(5):226-9. Review.
    PMID: 12765832 [PubMed - indexed for MEDLINE]


  24. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F.
    Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
    Mol Cell. 2003 Mar;11(3):571-5.
    PMID: 12667442 [PubMed - indexed for MEDLINE]


  25. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.
    TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
    Curr Biol. 2003 Sep 2;13(17):1459-68.
    PMID: 12956947 [PubMed - indexed for MEDLINE]


  26. Washietl S, Eisenhaber F.
    Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses.
    BMC Bioinformatics. 2003 Nov 7;4:55.
    PMID: 14604445 [PubMed - indexed for MEDLINE]


  27. Cserzö M, Eisenhaber F, Eisenhaber B, Simon I.
    On filtering false positive transmembrane protein predictions.
    Protein Eng. 2002 Sep;15(9):745-52.
    PMID: 12456873 [PubMed - indexed for MEDLINE]


  28. Ivanov D, Schleiffer A, Eisenhaber F, Mechtler K, Haering CH, Nasmyth K.
    Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion.
    Curr Biol. 2002 Feb 19;12(4):323-8.
    PMID: 11864574 [PubMed - indexed for MEDLINE]


  29. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence.
    J Mol Biol. 2002 Apr 5;317(4):541-57.
    PMID: 11955008 [PubMed - indexed for MEDLINE]


  30. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences.
    J Mol Biol. 2002 Apr 5;317(4):523-40.
    PMID: 11955007 [PubMed - indexed for MEDLINE]


  31. Novatchkova M, Eisenhaber F.
    Can molecular mechanisms of biological processes be extracted from expression profiles? Case study: endothelial contribution to tumor-induced angiogenesis.
    Bioessays. 2001 Dec;23(12):1159-75. Review.
    PMID: 11746235 [PubMed - indexed for MEDLINE]


  32. Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T.
    Regulation of chromatin structure by site-specific histone H3 methyltransferases.
    Nature. 2000 Aug 10;406(6796):593-9.
    PMID: 10949293 [PubMed - indexed for MEDLINE]


  33. Eisenhaber B, Bork P, Eisenhaber F.
    Prediction of potential GPI-modification sites in proprotein sequences.
    J Mol Biol. 1999 Sep 24;292(3):741-58.
    PMID: 10497036 [PubMed - indexed for MEDLINE]
 

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